Flonicamid
After 30d, flonicamid (pyridyl label) is highly mineralised in soil (47 - 56.6 %) and unextractable RA is in the range 29.6 - 43.3 %. Degradation involves hydrolosis of the amide bond to give TFNA = nicotinic acid derivative (max. 12.2 - 36.4 % after 1 - 3 d) and then hydroxylation of the pyridyl ring to give TFNA-OH (max. 12.1 - 21.3 % after 2 - 7 d). Another pathway involves hydrolosis of the cyano group to give TFNG-AM = amide derivative of flonicamid (max. 7.8 - 10.2 % after 0.33 - 2 d) and then oxidation to TFNG = acid derivative of flonicamid (< 3.9 %, no tendency to accumualte) which undergoes hydrolosis of the amide bond to give TFNA-AM = nicotinamide derivative (max. 7.6 % after 7d, minor pathway) or TFNA (major pathway). The study on degradation of TFNA-AM shows that little amounts of TFNA and TFNA-OH are derived from this metabolite.