Sedaxane
The degradation of sedaxane under aerobic laboratory soil conditions produced two main metabolites (CSAA798670 and CSCD465008). CSAA798670, was measured in the 14C-pyrazole labelled sedaxane aerobic soil studies at levels up to 6.1%AR respectively, and CSCD465008, formed via cleavage of the carboxamide link, was measured at levels up to 31.9% in the 14C-pyrazole labelled Sedaxane aerobic soil study. Maximum levels of non-extractable radioactivity were 58%AR from both phenyl and pyrazole labelled sedaxane laboratory soil degradation studies. This un-extracted residues fraction was shown to be a true "bound" residue, the majority of which (approximately 65-75 %) was associated with the humin fraction of the soil organic matter. The remainder was associated with the fulvic acid fraction. Levels of radioactivity associated with carbon-dioxide were high within the phenyl and pyrazole labelled study, increasing to 25.4 and 22.7% AR over the 1 year study duration for the phenyl and pyrazole labels respectively. The pattern of degradation products observed during the aerobic phase remained consistent during the anaerobic phase. Under anaerobic conditions no metabolites > 0.5% of applied 14C sedaxane were measured in soil. Mineralisation to carbon-dioxide was low (<5%) and un-extractable residues also remained low (<16%).