Triticonazole (RPA 400727)
The metabolism of triticonazole (RPA 400727) in soil starts with the hydroxylation to many different, but closely related, dihydroxy-metabolites. RPA 406341, RPA 407922 and RPA 404766 were found as the predominant (dihydroxy) soil metabolites. In minor side reactions further metabolites as RPA 406780, RPA 404886 and RPA 406203 could be observed and identified. Possibly the dihydroxy-metabolites may form trihydroxy-compounds. But all compounds subsequently degrade via soil bound species to give unextractable soil bound residues and carbon dioxide. The degradation of triticonazole is microbially mediated. The rates of degradation in aerobic soil under laboratory conditions (22°C-25°C), as presented in the reports, ranged from a half life of 145 days to a half life of 349 days (or 616 days if the biphasic nature of the degradation curve was not considered) with a mean of 269 days. These values were recalculated using modern software (TopFit 2.0) and the range was reduced to 151 days to 429 days with a mean of 237 days. Degradation was reduced at lower temperatures. At 10°C half lives between 224-707 days were derived. Additionally one extrapolated DT50 value was 614 days. Under anaerobic conditions there was little degradation so the rate could not be reliably calculated and can only be described as very slow. The major soil metabolites of triticonazole showed very different degradation behaviour. For RPA 407922 laboratory DT50 values (20°C) between 3.7 and 5.1days were found. For RPA 406341 and RPA 404766 the values were in the range of 165-330 days (1st order kinetics) and 31-46 days (1st order kinetics) respectively.