Fluquinconazole
The route of degradation of Fluquinconazole was determined in laboratory aerobic soil metabolism studies and additionally in the laboratory anaerobic and soil photolysis studies. The aerobic and anaerobic soil metabolism studies, and the soil photolysis study also enabled the derivation of degradation rates for Fluquinconazole. Further studies undertaken using Fluquinconazole degradation products as the starting test material, these studies provide additional information on the route and rate of degradation of Fluquinconazole and its primary metabolites. Rates of degradation for Fluquinconazole were also determined under field conditions in 12 trials across Europe (France, Germany, and the UK), covering a wide variety of soil types and climatic conditions. The initial breakdown of Fluquinconazole in soil is principally through a hydrolytic (abiotic) reaction that results in the formation of 3-(2,4-dichlorophenyl)-6-fluoro-quinazolin-2,4(3H)- dione (Dione) and 1,2,4-triazole (Triazole). These major metabolites appear to be further metabolised by microbial action. In the case of the Dione metabolite, this is further metabolised to the N-methyl derivative, 2-[3-(2,4-dichlorophenyl)ureido]-5-fluorobenzoic acid. For the Triazole metabolite further degradation is more complicated as hydroxylation may form Triazolone (1,2-dihydro-1,2,4-triazolone), or conjugation may give rise to triazolyl alanine and triazolyl acetic acid with the possibility of interconversion between triazolyl alanine and triazolyl acetic acid, and between triazolyl acetic acid and Triazole itself. Fluquinconazole is ultimately converted to carbon dioxide and bound residues via metabolism of the two principal degradation products.