Cocaine is an addictive, tropane alkaloid from the plant Erythroxylon coca. In addition, cocaine is a topical anesthetic, potent central nervous system stimulant, adrenergic blocking agent, and abused drug ([http://www.ncbi.nlm.nih.gov/pubmed/12242397|Kutchan, 1995]). Annual production of cocaine is on the order of 800 metric tons (U.S. NDIC, 2006). In bacteria, cocaine breakdown is initiated by cocaine esterase, which creates ecgonine methyl ester and benzoate. Ecgonine methyl esterase cleaves ecgonine methyl ester into ecgonine and methanol. The ecgonine is then transformed to pseudoecgonine by pseudoecgonine epimerase. Pseudoecgonyl-CoA synthase adds coenzyme A to pseudoecgonine to make pseudoecgonyl-CoA, which is subsequently metabolized to CO2, possibly in a manner similar to tropine in the atropine pathway ([http://www.ncbi.nlm.nih.gov/pubmed/8572717|Lister et al., 1996]).