Ketoprofen
Ketoprofen (2-(3-Benzoylphenyl)propanoic acid) is a non-steroidal anti-inflammatory drug found in waste water treatment plants. It is used as a non-prescription drug and a topical application of ketoprofen has the side effect of photoallergic contact dermatitis ([http://www.ncbi.nlm.nih.gov/pubmed/18279154|Devleeschouwer et al., 2008]). Ketoprofen degradation by a microbial consortium shown below proceeds along the pathway known for biphenyl and other compounds. The metabolites between ketoprofen and 2-{3-[Carboxylato(hydroxy)methyl]phenyl}propanoate are proposed. The latter compound and 2-[3-(Carboxylatocarbonyl)phenyl]propanoate were observed in high concentrations ([http://www.ncbi.nlm.nih.gov/pubmed/15979124|Quintana et al., 2005]). White-rot fungus Trametes versicolor degrades ketoprofen. The initial degradation is reduction of the ketone group, to form 2-[(3-Hydroxy(phenyl)methyl)phenyl]-propanoic acid, the first metabolite below. The metabolites 2-(3-Benzoyl-4-hydroxyphenyl)-propanoic acid and 2-[3-(4-Hydroxybenzoyl)phenyl]-propanoic acid, hydroxylated derivatives, were observed in minor quantities ([http://www.ncbi.nlm.nih.gov/pubmed/19913277|Marco-Urrea et al., 2010]).