1-Naphthoic Acid
Substituted and non-substituted naphthoic acids are excreted by various bacteria, fungi, and algae as dextoxification/biotransformation products of methyl naphthalenes, phenanthrene and anthracene. In bacterial systems, naphthoic acids have been shown to accumulate in the spent medium when Pseudomonas putida CSV86 was grown in the presence of 1- and 2- methylnaphthalene ([http://www.ncbi.nlm.nih.gov/pubmed/8042906|Mahajan et al. 1994]). [http://www.ncbi.nlm.nih.gov/pubmed/7710320|Phale et al. (1995)] reported the pathway for metabolism of 1-naphthoic acid by a soil bacterium, Pseudomonas maltophilia (now Stenotrophomonas maltophilia) CSV89. The degradation of 1-naphthoic acid is initiated by double hydroxylation of the aromatic ring adjacent to the one bearing the carboxyl group, resulting in the formation of 1,2-dihydroxy-8-carboxynaphthalene. The resultant diol was oxidized via 2-hydroxy-3-carboxy benzalpyruvate, 3-formyl salicylate, 2-hydroxyisophthalate, salicylate and catechol to TCA cycle intermediates, thus serving as the sole source of carbon and energy.