Nitroguanidine derivative → Urea derivative<br><br>Comments:<br>This rule handles the 'magic nitro' pathway and includes reduction of nitroguanidine to the corresponding aminoguanidine derivative, cleavage of the amine to form a guanidine metabolite, and hydrolysis to yield the urea derivative (<a href="http://www.ncbi.nlm.nih.gov/pubmed/19285027">Pandey et al., 2009</a>).
