4-Aminophenol derivative &rarr; 1,4-Dihydroxybenzenoid<br>4-Nitroaniline derivative &rarr; 4-Nitrophenol derivative<br>2-Aminophenol derivative &rarr; <i>vic</i>-Dihydroxybenzenoid<br>3-Aminophenol derivative &rarr; 1,3-Dihydroxybenzenoid<br><i>o</i>-Benzoquinone derivative &rarr; <i>vic</i>-Dihydroxybenzenoid<br><br>Comments:<br>This rule handles the aminophenol pathway. It includes initial oxidation followed by rapid hydrolysis of an <i>o</i>-, <i>m</i>- or <i>p</i>-aminophenol derivative to form an <i>o</i>-, <i>m</i>- or <i>p</i>-benzoquinone, respectively (bt0105). The <i>p</i>-benzoquinone intermediate is quickly reduced to a 1,4-dihydroxybenzenoid (bt0107), while the <i>o</i>-benzoquinone intermediate is similarly reduced to a <i>vic</i>-dihydroxybenzenoid. This rule handles the known benzoquinone intermediates in this pathway, based on <a href="http://www.ncbi.nlm.nih.gov/pubmed/10831408">Zhao et al., 2000</a> and <a href="http://www.ncbi.nlm.nih.gov/pubmed/10749534">Kutty et al., 2000</a>. This rule also handles the 5-nitroanthranilate amidohydrolase reaction, which might include a transient benzoquinone intermediate, based on <a href="http://www.ncbi.nlm.nih.gov/pubmed/20081004">Qu and Spain (2010)</a>.