2-unsubstituted Quinoline derivative → Hydroquinolin-2-one derivative<br>4-unsubstituted Quinoline derivative → Hydroquinolin-4-one derivative<br><br>Comments:<br>This rule oxygenates at the 2 position of the hetero-ring in 3-methyl, 4-methyl and unsubstituted quinolines. Oxygenation occurs at the 4 position for 2-methyl and unsubstituted quinolines.
