2-Ketocarboxylate → Carboxylate + CO<sub>2</sub><br><br>Comments:<br>After decarboxylation, some 2-ketocarboxylates transiently form an aldehyde, but this is quickly oxidized to the carboxylate. Others directly form the carboxylate, and the carboxylate is shown here. The rule does not decarboxylate 2-oxoacids that are cleaved to remove pyruvate or similar compounds rather than CO<sub>2</sub>, such as 2-oxo-3-ene, 2-oxo-4-imine, and 2,4-dioxo acids.
