1,2-Dihydroxypolyaromatic &rarr; 1-Hydroxy-2-carboxyaromatic<br>1,2-Dihydroxybenzothionoid &rarr; Benzothionate<br>Dihydroxyfluorene derivative &rarr; Carboxy-1-indanone derivative<br><br>Comments:<br>This rule handles the upper naphthalene pathway, and includes dioxygenation of selected polyaromatics to form a 2-hydroxy-2-carboxychromene derivative, isomerization to the <i>trans</i>-enoate, dioxygenation of benzothionoids and isomerization to the <i>trans</i>-enoate, combined dioxygenation and isomerization of other polyaromatics, aldolytic cleavage of the pyruvate group (not shown) leaving an aldehyde, and oxidation of the aldehyde to a carboxylate (bt0003). The rule does not handle intermediate metabolites in the upper naphthalene pathway.