aliphatic Phosphoester &rarr; Alcohol<br>aliphatic Phosphodiester &rarr; Alcohol + aliphatic Phosphoester<br>aliphatic Phosphotriester &rarr; Alcohol + aliphatic Phosphodiester<br>aliphatic Thiophosphoester &rarr; Alcohol + aliphatic Thiophospate<br><br>Comments:<br>Hydrolysis of phosphate esters. Depending on compound and environment, some of these may be spontaneous. Others are catalyzed by microbial phosphatases, such as alkaline phosphatase (<a href="http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/1/3/1.html">EC 3.1.3.1</a>), acid phosphatase (<a href="http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/1/3/2.html">EC 3.1.3.2</a>), and organophosphate hydrolase (<a href="http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/1/8/1.html">EC 3.1.8.1</a>) This rule also handles thiophosphoester derivatives.